Activation of Glycine and Extrasynaptic GABAA Receptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis
Figure 8
Taurine-mediated tonic conductance via extrasynaptic glycine and GABA receptors on SG neurons. (a) The representative trace illustrated that strychnine 2 μM mediated an outward shift of holding current by blocking glycine-mediated neurotransmission and blocked the taurine-induced synaptic currents except -mediated extrasynaptic current. (b) The bar graph showing the comparison of RMS noise in intact condition, in the presence of strychnine 2 μM and in the spontaneous application of taurine 1,000 μM and strychnine 2 μM (**). Holding potential was −60 mV.
