System Consolidation of Spatial Memories in Mice: Effects of Enriched Environment

Figure 1

(a) Performances of SC (𝑛=24) and EE (𝑛=24) mice in the MWM. There is a significant learning effect (two-way RM ANOVA, 𝑃=0.016), and a housing condition × day interaction (two-way RM ANOVA post hoc analysis Holm-Sidak method, for day 4, 𝑃=0.005; for day 5, 𝑃=0.001). ^∗=statistical significance; error bars = s.e.m. (b) Evaluation of spatial memory for SC (1 day 𝑛=5; 10 days 𝑛=5; 20 days 𝑛=5; 30 𝑛=5, 50 𝑛=4) and EE (1 day 𝑛=5; 10 days 𝑛=5; 20 days 𝑛=5; 30 𝑛=5; 50 𝑛=4) mice. Time spent in the target zone (𝑇), where the platform was placed, versus other equivalent zones (𝑂), for recall probe tests. One-way ANOVA, post hoc analysis Holm-Sidak method, 1 day probe test: in SC group, 𝑇 versus 𝑂,  𝑃=0.044; in EE group, 𝑇 versus 𝑂,  𝑃=0.036; 10 days probe test: in SC group, 𝑇 versus 𝑂,  𝑃=0.037; in EE group, 𝑇 versus 𝑂,  𝑃=0.043; 20 days probe test: in SC group, 𝑇 versus 𝑂,  𝑃<0.01; in EE group, 𝑇 versus 𝑂,  𝑃=0.048; 30 days probe test: in SC group, 𝑇 versus 𝑂,  𝑃=0.025; in EE group, 𝑇 versus 𝑂,  𝑃=0.048; 50 days probe test: in SC group, 𝑇 versus 𝑂,  𝑃=0.070; in EE group, 𝑇 versus 𝑂,  𝑃=0.226. ^∗=statistical significance; error bars = s.e.m.

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(b)