System Consolidation of Spatial Memories in Mice: Effects of Enriched Environment

Figure 4

c-Fos protein expression in MEnt and pPta. MEnt: two-way ANOVA post hoc analysis Holm-Sidak method, HC-SC versus HC-EE 𝑃=0.914; statistical significance for EE versus HC-EE at 10, 20, 30 and 50 days. Statistical difference between EE and SC at 1 day, 𝑃=0.782; at 10, 20, 30 and 50 days, 𝑃<0.01. Statistical difference within EE group were found between 1 day versus 10, 20, 30 and 50 days, and 20 days versus 10, 30 and 50 days, all 𝑃 values < 0.05. pPta: two-way ANOVA post hoc analysis Holm-Sidak method, HC-SC versus HC-EE 𝑃=0.497; statistical significance for EE versus HC-EE at 10, 20, 30 and 50 days, all 𝑃 values < 0.05. Statistical difference between EE and SC at 1 day, 𝑃=0.300; at 10 and 20 days, 𝑃<0.01; at 30 days, 𝑃=0.084; at 50 days, 𝑃=0.055. Statistical difference within EE group were found between 1 day versus 20, 30 and 50 days, and 20 day versus 10 and 30 days, all 𝑃 values < 0.05. Statistical difference within SC group were found between 1 and 30 days, and 10 day and 30 days, all 𝑃  values < 0.05. ^■Statistical significance between EE and HC-EE; ^□statistical significance between SC and HC-SC; ^∗statistical  significance between EE and SC; ^§=statistical significance for factor day within EE group; error bars = s.e.m.