Fluoxetine Dose and Administration Method Differentially Affect Hippocampal Plasticity in Adult Female Rats

Figure 2

Mean (±SEM) serum levels of fluoxetine (a, c) and norfluoxetine (b, d) (ng/mL). (a, b) There were significantly higher serum levels of fluoxetine/norfluoxetine in the animals receiving 10 mg/kg/day of fluoxetine via minipump. Serum levels were significantly lower in the morning and were significantly higher in the minipump group (0.000001<𝑃<0.015). (c, d) At sacrifice, serum from trunk blood revealed significantly higher levels of fluoxetine/norfluoxetine in the animals receiving 10 mg/kg/day of fluoxetine via minipump (0.00001<𝑃<0.03). (𝑛=6/group). ** denotes 10 mg significantly different from all other groups.

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