BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex
Figure 1
BACE1 KO mice exhibit stronger basal excitatory synaptic transmission and lack experience-dependent homeostatic regulation in superficial layers of V1. (a) In WT mice, 2 days of DE significantly increased the average amplitude of mEPSCs, which reversed to NR levels with 2 hours of LE (one-factor ANOVA: , Newman-Keuls post hoc test: ). Left: comparison of average mEPSC amplitude. Right: average mEPSC traces from each group. (b) Cumulative probability graph comparing the mEPSC amplitude distribution of normal-reared WT (black dotted line) and KO (gray solid line). There was a statistically significant difference between WT and KO (Kolmogorov-Smirnov test: ). (c) In KO mice, there was no significant difference in the average mEPSC amplitude across groups (one-factor ANOVA: ). Left: comparison of average mEPSC amplitude. Right: average mEPSC traces from each group.
