BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex

Figure 3

BACE1 KOs exhibit normal intrinsic excitability in L2/3 of V1. (a) Left: comparison of average action potential number with increase in current injection normalized to Rheo base (two-factor ANOVA: 𝑃>0.8). 𝑁=10 cells in each group (from 2 WT and 3 KO mice, 2-3 slices per mouse). Right: example of overlayed voltage traces taken at −40 pA (light gray), +40 pA (dark gray), and +120 pA (black) from Rheo base. (b–e) Comparison of average Rheo base (b), resting membrane potential (c), action potential threshold (d), and input resistance (e) measured in current clamp. Student’s 𝑡-test: 𝑃>0.6.

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