Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats

Figure 4

Inhibitory effects of GAS on Aβ _1–42-induced increase in spontaneous discharge in EC region. (a) Representative traces of firing rate of EC neurons after the application of saline (upper), GAS alone (middle), or Aβ _1–42 plus GAS (lower). Saline or GAS alone did not exert any obvious effect on the firing activities. Application of the GAS decreased the spontaneous discharge of Aβ _1–42-induced hyperexcitation. (b) Time-response curves for saline, GAS alone, Aβ _1–42 alone, and Aβ _1–42 plus GAS groups on the firing rates of EC neurons (, versus baseline values). (c) Histograms showing the mean discharge rate of EC neurons in different groups at 2000 s after injection (NS, no significant difference versus vehicle group, ^# versus saline group, ).

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