Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats

Figure 6

Inhibitory effects of GAS on Aβ _1–42-elicited inward currents in EC neurons. (a) Aβ _1–42-induced neuronal hyperexcitation was significantly inhibited in the presence of GAS. (b) Group data of 8 tested EC neurons showing the Aβ _1–42-induced changes in the firing rate calculated at 5 s intervals. (c) 300 nM Aβ _1–42 elicits inward currents in an EC neuron. GAS blocked the Aβ _1–42-induced inward currents. (d) Group data of 6 tested EC neurons. The pretreatment of GAS decreased Aβ _1–42-elicited inward currents in a dose-dependent manner (^#, ^## versus Aβ _1–42 alone group, , ).

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