Protective Effects of Ginkgo biloba Extract EGb 761 against Noise Trauma-Induced Hearing Loss and Tinnitus Development

Figure 4

Results of the gap-noise PPI of the ASR in four exemplary animals. Given are the mean response amplitudes in mN (±standard deviation) for the two noise conditions: without gap (open bars) and with gap (filled bars) before (blue) and after (red) the trauma for all 3 frequencies tested (averaged for both gap noise paradigms). The upper two animals received the vehicle and the lower two animals received the EGb 761 extract before the trauma. All gap conditions produced significantly (𝑡-tests) lower ASR amplitudes before the trauma. In some animals (KS 51 and KS 16) this was also true for the “posttrauma” condition and was a first indication for NT categorization. In other cases (KS 42 and KS 07) gap detection was impaired and did not show any significant change after the trauma at least at some frequencies; this was a first indication of T categorization (cf. Section 2).