Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF

Table 2

Neurotrophic factors, Eph receptors, and GTPase levels.

	Gene	Sham	Saline	PEDF
NFs	NT-3	1.295 ± 0.121	0.849 ± 0.146	0.796 ± 0.114*
	GDNF	1.298 ± 0.134	0.925 ± 0.122	1.794 ± 0.149^* ##
	BDNF	1.069 ± 0.113	1.276 ± 0.256	1.126 ± 0.138
	FGF-2	1.208 ± 0.139	1.113 ± 0.067	1.117 ± 0.091
Ephs	EphA6	0.915 ± 0.070	0.944 ± 0.114	1.210 ± 0.179
	EphB2	0.935 ± 0.062	0.915 ± 0.062	1.008 ± 0.076
GTPase	RhoA	1.132 ± 0.115	1.083 ± 0.063	1.070 ± 0.070

Relative gene expression of the neurotrophic factors (NFs) NT-3, GDNF, BDNF, and FGF-2, the EphA6 and EphB2 receptors, and the RhoA in ventral region of the spinal cord of Sham, Saline, and PEDF groups. *𝑃<0.05 difference between PEDF and Sham groups and ^##𝑃<0.05 the difference between PEDF and Saline groups by means of two-way ANOVA followed by Bonferroni posttest. Means ± s.e.m., 𝑛=6–8.