Adult Neuroplasticity: More Than 40 Years of Research

Figure 1

A schematic view on adult neurogenesis. Neuronal progenitor cells are generated in the subventricular zone (SVZ) and in the dentate gyrus (DG) of the hippocampal formation (Hip). (1) In the SVZ, neuroepithelial progenitor cells are generated that migrate through the RMS (rostral migratory stream) to the olfactory bulb (OB). They differentiate to mature neurons and are integrated as functional elements into the neuronal olfactory circuitry. (2) In the DG, quiescent neural progenitors (a) become amplifying neural progenitors (b) that differentiate first to neuroblasts (c), then to immature neurons (d), and finally to functionally mature granule neurons (e).