Dual Effect of Exogenous Nitric Oxide on Neuronal Excitability in Rat Substantia Gelatinosa Neurons
Figure 1
Effect of 1 mM and 10 μM SNP on the membrane excitability in substantia gelatinosa (SG) neurons of the spinal cord. (a) Current-clamp recording of membrane potentials of SG neurons showing the dual effect of SNP. SNP (1 mM) induced membrane hyperpolarization, whereas SNP (10 μM) elicited membrane depolarization. (b) Representative current traces of SG neurons recorded at a holding potential of −60 mV. SNP (1 mM) induced an outward current, whereas SNP (10 μM) induced an inward current. (c) Bar graphs show the membrane potential changes evoked by different concentrations of SNP. (d) Bar graphs show the amplitude of current changes induced by different concentrations of SNP. Mean ± SEM.
