Active Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Regulates NMDA Receptor Mediated Postischemic Long-Term Potentiation (i-LTP) by Promoting the Interaction between CaMKII and NMDA Receptors in Ischemia

Figure 2

(a) Sequential brain T2-w MRI in an individual mouse with photothrombotic lesion. White arrows indicate infarct region. (b) A series of representative brains stained with TTC after photothrombotic lesion. Pale staining indicates infarct region. (c) Detected by Western blotting, a potentiation of NMDAR in TIF caused by the photothrombotic lesion 1 hr after modeling was shown. (d) Statistical plots of data showing the effects of photothrombotic lesion (0 hr after PT, 1.22±0.08, 𝑛=5, ^∗𝑃<0.05; 1 hr after PT, 1.39±0.07, 𝑛=6, ^∗𝑃<0.05; 12 hr after PT, 1.05±0.07, 𝑛=5, 𝑃>0.05).