Nociceptive Neurons Differentially Express Fast and Slow T-Type Ca²⁺ Currents in Different Types of Diabetic Neuropathy

Figure 4

PDN-specific changes in steady-state inactivation of T-currents in NTCN neurons. Each column demonstrates the mean and SEM of half-inactivation potential of steady-state inactivation (SSI) calculated for 13 “fast” and 7 “slow” neurons of control group (C), 7 neurons of hyperalgesic group (D+), 5 “fast” and 3 “slow” neurons of hypoalgesic group (D−), and 8 “fast” and 4 “slow” neurons of normalgesic group (Dn). The results demonstrate that a depolarization shift in SSI was observed for the fast T-current in a case of hyperalgesia and for the slow T-current in norm- and hypoalgesia. ANOVA between all columns produced 𝑃<0.02. ***𝑃<0.001 (𝑡-test for merged “C, fast,” “C, slow,” and “D−, fast,” “Dn, fast” versus merged “D+, fast,” “D−, slow,” and “Dn, slow”). n.s.: not significant (ANOVA).