Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia

Figure 5

Colocalization of the majority of MCM2-positive cells with Iba1 in the hippocampal CA3 region of control subjects, iLBD cases and PD patients. (a–f) Representative confocal laser scanning microscopical images of double-immunofluorescent stained sections revealed that the majority of the MCM2-positive cells show colocalization with the microglial marker Iba1 (arrows in (c), (f), (i) and (j), and (k) and (l)). Iba1-positive microglia are depicted in green (a, d, and g) and MCM2 in red (b, e, and h). (j–l) Higher magnification of colocalization (l) between Iba1-positive microglia ((j), green) and MCM2 ((k), red); bar (a–i) = 40 μm; (j–l) = 10 μm.

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