Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia

Table 1

Clinical and neuropathological information of all included subjects.

C. number	Sex	Age	PMD (hrs.)	Braak staging		D	Region	Cause of death
				AD (NFT/A)	PD (-syn.)
1	F	92	7:00	1A	0	NDC	HC	Acute death, pulmonary emboli
2	M	88	4:23	2A	0	NDC	HC	Gastrointestinal bleeding
3	F	84	6:55	1O	0	NDC	HC	Myelodysplasia
4	M	82	5:10	1O	0	NDC	HC	Unknown
5	M	62	7:20	1O	0	NDC	HC	Unknown
6	F	83	3:20	1B	0	NDC	HC	Legal Euthanasia
7	F	84	4:45	1O	0	NDC	HC	Heart failure
8	F	85	5:19	2B	0	NDC	HC	Natural death, pulmonary disease
9	M	78	<17:00	1O	0	NDC	HC	Heart failure
10	F	82	5:10	2O	2	iLBD	HC	Heart failure
11	M	86	4:00	2B	1	iLBD	HC	Respiratory insufficiency
12	M	56	5:00	0 (—)	2	iLBD	HC	Pneumonia
13	F	91	4:50	(—)	1	iLBD	HC	Exhaustion, colon carcinoma
14	M	84	7:20	1B	3	iLBD	HC	Prostate cancer
15	M	87	10:20	1A	1	iLBD	HC	Pneumonia, heart failure
16	M	83	4:50	1A	4	PDD	HC	Heart failure
17	F	59	9:35	1A	4	PD	HC	Shock due to blood loss in digestive tract
18	F	90	4:50	1B	4	PDD	HC	Unknown
19	F	70	7:05	2B	6	PDD	HC	Haematemesis by oesophagitis
20	M	84	9:00	1A	5	PDD	HC	Pneumonia and dehydration
21	F	87	5:25	2B	6	PDD	HC	Pneumonia
22	M	73	5:35	1A	5	PDD	HC	Direct cause unknown (morphine)
23	M	83	5:15	1B	6	PDD	HC	Pneumonia
24	F	84	7:25	2B	5	PD	HC	Old age, shortness of breath
25	F	96	7:10	1B	5	PD	HC	Old age
26	M	86	5:10	2B	5	PD	HC	Heart failure
27	M	71	5:50	1A	6	PD	HC	Respiratory failure
28	F	83	6:05	1O	4	PDD	HC	Cachexia by dementia, infarction
29	M	83	6:35	1B	6	PDD	HC	Pneumonia

D: clinical diagnosis; PMD: postmortem delay; NFT: neurofibrillary tangles; Aβ: amyloid-beta; -syn: alpha-synuclein; NDC: nondemented control subject; iLBD: incidental Lewy Body disease; PD: Parkinson’s disease; PDD: Parkinson’s disease with dementia; HC: hippocampus.