Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG

<div>MeCbl inhibited spontaneous activity (SA) of A-type neurons of the compressed DRG in a dose-dependent way. (a) Time histogram shows that the application of MeCbl (300 <i>μ</i>M) decreases the basal firing rate of an A-type dorsal root fiber<i> in vivo</i>. Three traces in right panel were showed firing patterns before (A), during (B) and wash (C) the application of MeCbl. (b) Time histogram shows the inhibitory effect of MeCbl in a dose-dependent manner. (c) The concentration-response curve shows the value for IC<sub>50</sub> (76 <i>μ</i>M) of MeCbl. (d) Schematic graph of whole-cell recording of DRG neurons and photography of medium-sized DRG neurons. Scale = 20 <i>μ</i>m. (e) MeCbl (10 <i>μ</i>M) inhibited the SA of one medium-sized DRG neuron of CCD group.</div>

Neural Plasticity

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Figure 3

Figure 3: Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG 

Figure 3 | Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG 