Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG

Figure 6

MeCbl inhibited the of medium-sized neurons of DRG neurons. (a) current is evoked by hyperpolarizing voltage steps from a holding potential of −60 mV. current amplitude is calculated from the difference between the steady-state and the instantaneous current. (b) Increased current density of medium-sized DRG neurons in CCD rats. ^#, compared with those of sham group. (c) Effects of MeCbl on the current density of medium-sized DRG neurons. , compared with those in the absence of MeCbl.

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