Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder

<table class="table-group" id="tab6"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left"> </td><td align="center" colspan="2">BDNF</td></tr><tr class="thead"><td align="left"> </td><td align="center"><svg height="9.7821pt" id="M27" style="vertical-align:-3.57194pt" version="1.1" viewbox="-0.0498162 -6.21016 7.42948 9.7821" width="7.42948pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M516 277C516 378 460 448 376 448C335 448 288 434 240 401C158 345 127 277 107 159C53 -161 38 -221 23 -247L28 -261C43 -260 95 -250 114 -226C122 -216 129 -199 146 -75C152 -29 157 0 164 31C182 9 206 -12 237 -12C267 -12 325 8 376 46C451 102 516 179 516 277ZM432 259C432 134 366 40 259 40C236 40 204 48 171 76L195 203C219 327 253 400 326 400C398 400 432 336 432 259Z" id="g113-239"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="539" vert-adv-y="539"></glyph.data></g></svg> (rho)</td><td align="center"><svg height="9.04777pt" id="M28" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -8.99795 8.4902 9.04777" width="8.4902pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="617" vert-adv-y="617"></glyph.data></g></svg> value</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Disease time</td><td align="center">.069</td><td align="center">.731</td></tr><tr><td align="left">IQ</td><td align="center">.069</td><td align="center">.732</td></tr><tr><td align="left">Digit span</td><td align="center">−.187</td><td align="center">.351</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Correlation among BDNF versus disease time, IQ, and digit span.

Neural Plasticity

tab6

Table 6

Table 6: Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder 

Table 6 | Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder 