Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat

<div>Most of the FG-labeled spinally projecting neurons in the RVM expressed p-mTOR. (a) Fluorescence photomicrograph showing the FG injection site in the lumbar spinal dorsal horn (SDH). (b) Camera lucida drawings show the rostrocaudal extent of the FG injection site at the different levels indicated, L1, L3, and L5. L1, L3, and L5 show the corresponding segments of the lumbar cord (DH: dorsal horn; CC: central canal). (c)–(e) Representative fluorescence photomicrographs showing p-mTOR (red) and FG (green) double-labeled neurons in the RVM. The double arrowheads indicate p-mTOR/FG double-labeled neurons (yellow), the arrowheads indicate FG single-labeled neurons, and the arrows indicate p-mTOR single-labeled neurons in the RVM. Scale bar = 500 <i>μ</i>m in (a) and 100 <i>μ</i>m in (e) (applied to (c)–(e)).</div>

Neural Plasticity

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Figure 3

Figure 3: Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat 

Figure 3 | Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat 