Table of Contents Author Guidelines Submit a Manuscript
Neural Plasticity
Volume 2015, Article ID 408136, 10 pages
http://dx.doi.org/10.1155/2015/408136
Review Article

The Potential Role of the NLRP3 Inflammasome as a Link between Mitochondrial Complex I Dysfunction and Inflammation in Bipolar Disorder

1Department of Pharmacology and Toxicology, University of Toronto, 1 King’s College Circle, Toronto, ON, Canada M5S 1A8
2Department of Psychiatry, University of Toronto, 1 King’s College Circle, Toronto, ON, Canada M5S 1A8
3Centre of Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8

Received 6 August 2014; Accepted 6 November 2014

Academic Editor: Rodrigo Machado-Vieira

Copyright © 2015 Helena Kyunghee Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [18 citations]

The following is the list of published articles that have cited the current article.

  • Hans O. Kalkman, and Dominik Feuerbach, “Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders,” Cellular and Molecular Life Sciences, vol. 73, no. 13, pp. 2511–2530, 2016. View at Publisher · View at Google Scholar
  • Zi-Teng Zhang, Xiu-Ming Du, Xiu-Juan Ma, Ying Zong, Ji-Kuai Chen, Chen-Lin Yu, Yan-Gang Liu, Yong-Chun Chen, Li-Jun Zhao, and Guo-Cai Lu, “Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome,” Journal Of Neuroinflammation, vol. 13, 2016. View at Publisher · View at Google Scholar
  • Danúbia Bonfanti Santos, Dirleise Colle, Eduardo Luiz Gasnhar Moreira, Mariana Appel Hort, Marcelo Godoi, Gael Le Douaron, Antonio Luiz Braga, Jamil Assreuy, Patrick Pierre Michel, Rui Daniel Prediger, Rita Raisman-Vozari, and Marcelo Farina, “Succinobucol, a Non-Statin Hypocholesterolemic Drug, Prevents Premotor Symptoms and Nigrostriatal Neurodegeneration in an Experimental Model of Parkinson’s Disease,” Molecular Neurobiology, vol. 54, no. 2, pp. 1513–1530, 2016. View at Publisher · View at Google Scholar
  • Ellen F Charles, Christophe G Lambert, and Berit Kerner, “Bipolar disorder and diabetes mellitus: evidence for disease-modifying effects and treatment implications.,” International journal of bipolar disorders, vol. 4, no. 1, pp. 13, 2016. View at Publisher · View at Google Scholar
  • Andrea Wieck, Rodrigo Grassi-Oliveira, Carine Hartmann do Prado, Thiago Wendt Viola, Laura Esteves Petersen, Bárbara Porto, Antônio Lúcio Teixeira, and Moisés Evandro Bauer, “Toll-Like Receptor Expression and Function in Type I Bipolar Disorder,” Brain, Behavior, and Immunity, 2016. View at Publisher · View at Google Scholar
  • Helena Kyunghee Kim, Ana Cristina Andreazza, Nika Elmi, Wenjun Chen, and L. Trevor Young, “Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: A potential mediator between mitoc,” Journal Of Psychiatric Research, vol. 72, pp. 43–50, 2016. View at Publisher · View at Google Scholar
  • Lawrence B. Afrin, “Mast Cell Activation Disease and the modern Epidemic of Chronic Inflammatory Disease,” Translational Research, 2016. View at Publisher · View at Google Scholar
  • George Anderson, Aude Jacob, Frank Bellivier, and Pierre Alexis Geoffroy, “Bipolar Disorder: The Role of the Kynurenine and Melatonergic Pathways,” Current Pharmaceutical Design, vol. 22, no. 8, pp. 987–1012, 2016. View at Publisher · View at Google Scholar
  • Katalin Lumniczky, Tünde Szatmári, and Géza Sáfrány, “Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Jian Fu, Haibin Sun, Yongzhe Zhang, Wei Xu, Chuan Wang, Yanwei Fang, and Jianhui Zhao, “Neuroprotective Effects of Luteolin Against Spinal Cord Ischemia–Reperfusion Injury by Attenuation of Oxidative Stress, Inflammation, and Apoptosis,” Journal of Medicinal Food, 2017. View at Publisher · View at Google Scholar
  • G. Morris, A. J. Walker, M. Berk, M. Maes, and B. K. Puri, “Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists,” Molecular Neurobiology, 2017. View at Publisher · View at Google Scholar
  • Ekaterina Sigitova, Zdeněk Fišar, Jana Hroudová, Tereza Cikánková, and Jiří Raboch, “Biological hypotheses and biomarkers of bipolar disorder,” Psychiatry and Clinical Neurosciences, vol. 71, no. 2, pp. 77–103, 2017. View at Publisher · View at Google Scholar
  • Elísabet Alcocer-Gómez, Beatriz Castejón-Vega, and Mario D. Cordero, “Stress-Induced NLRP3 Inflammasome in Human Diseases,” 2017. View at Publisher · View at Google Scholar
  • Parvin Kumar, Paschalis Efstathopoulos, Vincent Millischer, Eric Olsson, Ya Bin Wei, Oliver Brüstle, Martin Schalling, J. Carlos Villaescusa, Urban Ösby, and Catharina Lavebratt, “Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Moisés E. Bauer, and Antonio L. Teixeira, “Inflammation in psychiatric disorders: what comes first?,” Annals of the New York Academy of Sciences, 2018. View at Publisher · View at Google Scholar
  • J. Blair Price, Carrie Bronars, Sophie Erhardt, Kathyrn R. Cullen, Lilly Schwieler, Michael Berk, Ken Walder, Sean L. McGee, Mark A. Frye, and Susannah J. Tye, “Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression,” Neuroscience & Biobehavioral Reviews, 2018. View at Publisher · View at Google Scholar
  • Helena Kyunghee Kim, Kathrin Tyryshkin, Nika Elmi, Harriet Feilotter, and Ana Cristina Andreazza, “Examining redox modulation pathways in the post-mortem frontal cortex in patients with bipolar disorder through data mining of microRNA expression datasets,” Journal of Psychiatric Research, 2018. View at Publisher · View at Google Scholar
  • S. V. Pirozhkov, N. N. Terebilina, and P. F. Litvitskiy, “A role of inflammasomes in the pathogenesis of neurological and mental diseases,” Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, vol. 118, no. 12, pp. 81, 2018. View at Publisher · View at Google Scholar