The Potential Role of the NLRP3 Inflammasome as a Link between Mitochondrial Complex I Dysfunction and Inflammation in Bipolar Disorder

Table 2

Characteristics of studies examining inflammatory cytokines in the central nervous system of patients with BD.

Author name	Article year	Sample size	Sample	Technique used	Cytokines examined
Rao et al. [52]	2010	10 BD, 10 control	Postmortem frontal cortex BA 24 and BA 46	Western plot, RT PCR, immunohistochemistry	NMDA receptors, NR-1 and NR-3A, IL-1β, IL-1R, MyD88, NF-kB (p50, p65), GFAP, iNOS, c-fos and CD11b, TNFα, neuronal nNOS,
Söderlund et al. [53]	2011	BD euthymic patients, r type I ( = 15) or type II ( = 15)	CSF	An immunoassay-based protein array multiplex system	IL-1b, IL-6,
Dean et al. [50]	2013	10 MDD, 10 BD, 19 SZ, 30 control	Postmortem CNS tissue, BA24 and BA46	Western plot, RT PCR	tmTNF-a, sTNF-a, TNF mRNA, TNFR1, TNFR2, IL-1beta, synaptophysin, PSD95, GFAP43, GFAP41, CD11b and pro-IL1B