| Outcome | studies | Manic vs. controls | Mania vs. euthymia | Depression vs. controls | Euthymia vs. control | Remission vs. control | BD vs. controls | Mania vs. depression | Early stage vs. control | Late stage vs. control | References |
| sIL-2R | 4 | + | + | + | + | + | + | + | | | [25, 27, 30, 45] | sIL-6R | 2 | | | | | | + | | | | [25, 41] | IFN-g | 6 | +− | − | | | − | − | | | | [29, 31, 40, 93, 94, 99] | TNF-a | 11 | + | | + | | | + | | + | + | [29, 32, 35–37, 40, 42, 47, 99, 101] | sTNFR1 | 7 | | | | + | | + | | | | [26, 37, 41, 44, 100, 101] | sTNFR2 | 6 | NS | | | | | | | | | [37, 100, 101] | TGF-b1 | 1 | | | | | | + | | | | [93] | IL-1b | 4 | − | | | | | | − | | | [40, 42, 47, 97] | IL-2 | 6 | − | | − | − | | − | | | | [29, 31, 40, 42, 94, 99] | IL-4 | 6 | +− | | | | | | + | | | [29, 42, 47, 93, 94, 99] | IL-5 | 2 | | | | | | | | | | [47, 99] | IL-6 | 8 | + | | + | − | | − | − | | | [29, 31, 36, 40, 42, 44, 97] | IL-8 | 2 | + | | + | | | | | | | [32, 47] | IL-10 | 9 | | | | − | | − | | | | [27, 29, 31, 32, 36, 40, 47, 94, 99] | IL-12 | 1 | | | | | | + | | | | [92] | IL-1 | 2 | | | | | | + | | | | [35, 40] | IL-1RA | 3 | + | + | | | | | | | | [26, 44, 94] | CRP | 2 | + | + | + | | | | + | | | [28, 96] | hsCRP | 2 | | | + | | | | | | | [34, 98] |
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