The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts

Table 1

Flowchart—selection of articles (see Figure 1).

Initial search
“Early age at onset” and “bipolar disorder”	“Early onset” and “bipolar disorder”	“Suicide attempts” and “bipolar disorder”	“Suicide” and “bipolar disorder”	“Marijuana” and “bipolar disorder”	“Cannabis” and “bipolar disorder”
626	1,017	1,069	2,289	190	143
Inclusion of the articles fulfilling the entry criteri (at least one)
“Early age at onset” or “early onset” and “bipolar disorder”		“Suicide attempts” or “suicide” and “bipolar disorder”		“Marijuana” or “cannabis” and “bipolar disorder”
51		44		59
Exclusion of repetitive and duplicate articles
17		13		19
Final analysis
34		31		40

(1) The selected study should provide data that allowed evaluating the age at onset of bipolar disorder.
(2) The paper should present the proportion of bipolar patients who used cannabis.
(3) Patients included in these studies should have had an early age at onset of BD or suicide attempts.