Neural Plasticity / 2015 / Article / Tab 2 / Review Article
The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts Table 2 Definitions of age at onset of bipolar disorder.
Study Design Sample (bipolar patients)a Very early age at onset (in years) Early age at onset (in years) Intermediate age at onset (in years) Late age at onset (in years)
Schürhoff et al., 2000b [10 ] Cross-sectional 210 — <18 — >40 Schulze et al., 2002b [17 ] Cross-sectional 169 — ≤20 — ≥35
Post et al., 2003b [18 ] Cross-sectional 320 (202 female; 118 male) — ≤18 — >18 Bellivier et al., 2003c [19 ] Cross-sectional 368 — Median age: 17.4 Median age: 25.1 Median age: 40.4 Perlis et al., 2004c [20 ] Cross-sectional 1,000 <13 13–18 — >18 Lin et al., 2006c [21 ] Cross-sectional 1,856 (211 probands) — ≤21 Mean age: 16.6 22–28 Mean age: 26 >28 Mean age: 34.7 Benazzi and Akiskal, 2008 [22 ] Cross-sectional 560d — <21 — >21 Hamshere et al., 2009c [23 ] Cross-sectional 1,369 — Limit: <22 mean age: 18.7 ± 3.7 Limit: 25–37 mean age: 28.3 ± 5.5 Limit: >40 mean age: 43.3 ± 9.1 Etain et al., 2012c [3 ] Cross-sectional 652 — <21 — ≥21
(based on Hamshere et al. 2009 [23 ]).
a Some studies do not classify the patients whose diagnosis was included.
b Age of both bipolar disorder (BD) type I and BD type II.
c Age of BD type I.
d 336 BD type II and 224 unipolar major depressive disorder.