Table of Contents Author Guidelines Submit a Manuscript
Neural Plasticity
Volume 2015, Article ID 453170, 11 pages
http://dx.doi.org/10.1155/2015/453170
Research Article

Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice

1Department of Neurosurgery, First Affiliated Hospital, Medical College, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
2Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
3Institute of Neuroscience and Collaborative Innovation Center for Brain Science, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China

Received 31 March 2015; Revised 13 September 2015; Accepted 14 September 2015

Academic Editor: James M. Wyss

Copyright © 2015 Zhen-Xing Zuo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. A.-S. Huijer, “Chronic pain: a review,” Journal Medical Libanais, vol. 58, no. 1, pp. 21–27, 2010. View at Google Scholar · View at Scopus
  2. M. C. Bushnell, M. Čeko, and L. A. Low, “Cognitive and emotional control of pain and its disruption in chronic pain,” Nature Reviews Neuroscience, vol. 14, no. 7, pp. 502–511, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. R. H. Dworkin, A. B. O'Connor, J. Audette et al., “Recommendations for the pharmacological management of neuropathic pain: an overview and literature update,” Mayo Clinic Proceedings, vol. 85, no. 3, supplement, pp. S3–S14, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. J. Keenan, R. J. Martin, A. M. Raggio et al., “High-amylose resistant starch increases hormones and improves structure and function of the gastrointestinal tract: a microarray study,” Journal of Nutrigenetics and Nutrigenomics, vol. 5, no. 1, pp. 26–44, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Zhang, C. Wang, L. Wang et al., “A novel analgesic isolated from a traditional Chinese medicine,” Current Biology, vol. 24, no. 2, pp. 117–123, 2014. View at Publisher · View at Google Scholar
  6. Z.-F. Wang, L.-L. Tang, H. Yan, Y.-J. Wang, and X.-C. Tang, “Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice,” Pharmacology Biochemistry and Behavior, vol. 83, no. 4, pp. 603–611, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Zhou, H. Y. Zhang, and X. C. Tang, “Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils,” Neuroscience Letters, vol. 313, no. 3, pp. 137–140, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Zhou and X. C. Tang, “Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons,” FEBS Letters, vol. 526, no. 1–3, pp. 21–25, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. L. S. Wang, J. Zhou, X. M. Shao, and X. C. Tang, “Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia–ischemia,” Brain Research, vol. 949, no. 1-2, pp. 162–170, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. J. N. Crawley, “Designing mouse behavioral tasks relevant to autistic-like behaviors,” Mental Retardation and Developmental Disabilities Research Reviews, vol. 10, no. 4, pp. 248–258, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Galeotti, C. Ghelardini, L. D. C. Mannelli, and A. Bartolini, “Antinociceptive profile of the natural cholinesterase inhibitor huperzine A,” Drug Development Research, vol. 54, no. 1, pp. 19–26, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Yu, D. K. Thakor, I. Han et al., “Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 8, pp. E746–E755, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Park, S. Schachter, and T. Yaksh, “Intrathecal Huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats,” Neuroscience Letters, vol. 470, no. 1, pp. 6–9, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. M.-M. Backonja and B. Stacey, “Neuropathic pain symptoms relative to overall pain rating,” Journal of Pain, vol. 5, no. 9, pp. 491–497, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Tappe-Theodor and R. Kuner, “Studying ongoing and spontaneous pain in rodents—challenges and opportunities,” European Journal of Neuroscience, vol. 39, no. 11, pp. 1881–1890, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. G. J. Bennett, “What is spontaneous pain and who has it?” Journal of Pain, vol. 13, no. 10, pp. 921–929, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. T. King, L. Vera-Portocarrero, T. Gutierrez et al., “Unmasking the tonic-aversive state in neuropathic pain,” Nature Neuroscience, vol. 12, no. 11, pp. 1364–1366, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. K. I. Vadakkan, Y. H. Jia, and M. Zhuo, “A behavioral model of neuropathic pain induced by ligation of the common peroneal nerve in mice,” The Journal of Pain, vol. 6, no. 11, pp. 747–756, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. X.-Y. Li, H.-G. Ko, T. Chen et al., “Alleviating neuropathic pain hypersensitivity by inhibiting PKMζ in the anterior cingulate cortex,” Science, vol. 330, no. 6009, pp. 1400–1404, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. S. R. Chaplan, F. W. Bach, J. W. Pogrel, J. M. Chung, and T. L. Yaksh, “Quantitative assessment of tactile allodynia in the rat paw,” Journal of Neuroscience Methods, vol. 53, no. 1, pp. 55–63, 1994. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Qu, T. King, A. Okun, J. Lai, H. L. Fields, and F. Porreca, “Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy,” Pain, vol. 152, no. 7, pp. 1641–1648, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Leger, A. Quiedeville, V. Bouet et al., “Object recognition test in mice,” Nature Protocols, vol. 8, no. 12, pp. 2531–2537, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. C. J. Woolf and M. W. Salter, “Neuronal plasticity: increasing the gain in pain,” Science, vol. 288, no. 5472, pp. 1765–1768, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Gao, C. Y. Zheng, L. Yang, X. C. Tang, and H. Y. Zhang, “Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide,” Free Radical Biology and Medicine, vol. 46, no. 11, pp. 1454–1462, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. I. Papp, S. Komoly, I. G. Szirmai, and T. Kovács, “Similarities between CSF-brain extracellular transfer and neurofibrillary tangle invasion in Alzheimer's disease,” Neurobiology of Aging, vol. 27, no. 3, pp. 402–412, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. G. B. Koelle, “Histochemical demonstration of reversible anticholinesterase action at selective cellular sites in vivo,” The Journal of Pharmacology and Experimental Therapeutics, vol. 120, no. 4, pp. 488–503, 1957. View at Google Scholar · View at Scopus
  27. J. S. Mogil, “Animal models of pain: progress and challenges,” Nature Reviews Neuroscience, vol. 10, no. 4, pp. 283–294, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. E. Navratilova and F. Porreca, “Reward and motivation in pain and pain relief,” Nature Neuroscience, vol. 17, no. 10, pp. 1304–1312, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. I. P. Kleggetveit and E. Jørum, “Large and small fiber dysfunction in peripheral nerve injuries with or without spontaneous pain,” The Journal of Pain, vol. 11, no. 12, pp. 1305–1310, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Gottrup, F. W. Bach, G. Juhl, and T. S. Jensen, “Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain,” Anesthesiology, vol. 104, no. 3, pp. 527–536, 2006. View at Publisher · View at Google Scholar · View at Scopus