Research Article

Age-Related Alterations in the Expression of Genes and Synaptic Plasticity Associated with Nitric Oxide Signaling in the Mouse Dorsal Striatum

Figure 1

Increased expression of GFAP in the dorsal striatum of old (group IV) mice. (a) Schematic diagram of a horizontal brain slice used for the histological and electrophysiological analysis. The region of counting the GFAP-expressing glial cells and field recording is marked by the green circle. (b) Schematic drawing of relative position of stimulating (S) and recording (R) electrodes in the region marked by the green circle in (a) dStr: dorsal striatum, CTX: cortex. (c) Relative levels of striatal GFAP mRNA in different age groups: group I (), group II (), group III (), and group IV (). (d) Examples of confocal microscope images with eGFP-GFAP fluorescent cells in striatal slices from a young and an old mouse. Scale bars: 100 µm.
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