Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices

<div>Presynaptic effect of chondroitin sulfate. (a) Time-course of averaged facilitation of fEPSP evoked by paired pulses at 50 ms intervals and applied every 15 s. Note the facilitation exerted by CS (300 <i>μ</i>M) applied during the time indicated by the top horizontal bar. (b) Representative fEPSPs recorded in response to paired stimuli separated by 50 interpulse intervals in control A and after 20 min of CS (300 <i>μ</i>M) application B. The amplitudes evoked correspond to the 40–50% of maximal response. Data are mean ± SEM of 14 slices evaluated.</div>

Neural Plasticity

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Figure 3

Figure 3: Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices 