Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices
Chondroitin sulfate enhanced short LTP in hippocampal slices. (a) Averaged time-course in control conditions (circle symbol) and CS-treated slices, with (triangle symbol) or without (square symbol) a brief period of tetanization (100 Hz, 1 s). Data were normalized to the mean value of the 20 min control period and expressed as the mean ± SEM/min ( slices). (b) Original traces showing representative fEPSP taken at the times indicated by the letters A (control), B (after CS perfusion), C (CS-treated slice after 2 min tetanisation), and D (CS-treated slice after 60 min tetanisation). (c) Time-course of normalised LTP. The baseline recorded before tetanus was considered as 100%.