Statins Promote Long-Term Recovery after Ischemic Stroke by Reconnecting Noradrenergic Neuronal Circuitry

Figure 5

Physiological recovery and behavioral tests relating to the NA circuitry. (a) Profiles of blood pressure in vehicle-treated or atorvastatin-treated mice after tFCI. (b) Effects of atorvastatin on behavioral parameters in the light/dark test. The light/dark test was performed at 30, 180, and 240 days after tFCI in mice. The effect on mouse behavior in the light/dark test was determined by p-test. Data presented are the mean value ± S.E.M, relative to the vehicle group. (c) Effects of atorvastatin on behavioral parameters in the aggression-intruder test in mice. Aggression-intruder test was performed at 30, 180, and 240 days after tFCI in mice. The effect on mouse behavior in the aggression-intruder test was determined by p-test. Data presented are mean value ± S.E.M, relative to the vehicle group.

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