Physiological Properties of Supragranular Cortical Inhibitory Interneurons Expressing Retrograde Persistent Firing

Table 1

Membrane and synaptic properties of fast-spiking nonpersistent firing (FS-nPF), non-fast-spiking nonpersistent firing (nFS-nPF), and non-fast-spiking persistent firing (nFS-PF) layer 2/3 interneurons. The column 1–3 represents the values between FS-nPF (1) and nFS-PF (3); meanwhile the column 2-3 represents the values between nFS-nPF (2) and nFS-PF (3).

Layer 2/3	FS-nPF (1)	nFS-nPF (2)	nFS-PF (3)	1–3	2-3
Resting Vm	−69.45 ± 1.14 mV (19)	−68.51 ± 0.78 mV (51)	−71.10 ± 0.96 mV (25)	>0.05	0.049
Spike threshold	−40.71 ± 1.04 mV	−41.15 ± 0.77 mV	−38.52 ± 0.95 mV	>0.05	0.042
mV to threshold	28.44 ± 1.64 mV	27.84 ± 1.01 mV	32.80 ± 1.50 mV	>0.05	0.008
Input resistance	123.39 ± 8.69 M	194.43 ± 11.03 M	116.33 ± 7.05 M	>0.05	<0.001
Spike half-width	0.36 ± 0.01 ms	0.60 ± 0.01 ms	0.68 ± 0.02 ms	<0.001	<0.001
sEPSCs frequency	—	4.84 ± 0.52 Hz (25)	5.78 ± 0.75 Hz (8)	—	>0.05
sEPSCs amplitude	—	14.15 ± 0.99 pA (25)	13.22 ± 1.89 pA (8)	—	>0.05
Soma size	146.90 ± 12.73 m^2 (7)	112.50 ± 5.85 m^2 (21)	84.44 ± 4.87 m^2 (6)	<0.001	0.037