Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis

Figure 4

Strategies used to study the processes related to the setting of the learning tag and the PRPs synthesis in BT models. Weak training induces short- but not long-term memory and sets a leaning tag (dashed circle). The strong experience or different drugs (dopaminergic and adrenergic agonists) induces the synthesis of PRPs (red circle) that can be used to allow memory consolidation for a weak learning (green path). The local infusion of different inhibitory drugs (i.e., αCAMKII, PKA inhibitors, PKMζ blocker, or NMDA receptor antagonist) in brain structures close to the weak training can interfere with the proper setting and/or maintenance of the learning tag, impairing the promotion of LTM (red path). The local infusion of different drugs (i.e., protein synthesis inhibitors, antisense oligonucleotides, or D1/D5-dopaminergic, b-adrenergic, and NMDA receptors antagonists) in the target structure at the moment of PRPs synthesis also impaired the promotion of LTM (red path). Kinase activity requirement of TrkB receptor for both processes has been shown using Knock-in mice (see [43, 46, 54, 63, 64, 89]).