(a)
(b)
(c)
Figure 5: Behavioral tagging in LTM-persistence. In the life of a memory could be at least two rounds of tags. (a) At the time of a weak training, a learning tag is set (dashed circle). However, as there are no PRPs synthesis, consolidation does not occur. (b) A strong training per-se triggers two processes: the setting of a learning tag and the synthesis of PRPs (red circle). The capture of these products by the learning tags led the formation of a LTM (usually tested 1 day after training). Moreover, we postulated that the strong training also induces in a delay fashion a second round of tagging (maintenance tag) emerging at 11 h after training (dashed-dotted circle). (c) A stronger training (persistence strong training), will allow memory to persist at least for a week (L-LTM). This persistent expression of memory could depend on the capability of a late established maintenance tag (dashed-dotted circle) to use/capture PRPs (red circle) derived of a late wave of protein synthesis. It was reported that this very strong training session induces a delay window of protein synthesis on which its memory persistence relies. Also, in the case of a strong training session (which induce only LTM), PRPs provided by a pharmacological intervention or by a behavioral experience can promote L-LTM if they are available around the time of the maintenance tag.