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Neural Plasticity
Volume 2015, Article ID 653727, 10 pages
http://dx.doi.org/10.1155/2015/653727
Research Article

Evolution of Apparent Diffusion Coefficient and Fractional Anisotropy in the Cerebrum of Asphyxiated Newborns Treated with Hypothermia over the First Month of Life

1Division of Newborn Medicine, Department of Pediatrics, Montreal Children’s Hospital, McGill University, Montreal, QC, Canada H3H 1P3
2MR Clinical Science, Philips Healthcare, Montreal, QC, Canada H2S 2J3
3Department of Pediatric Radiology, Montreal Children’s Hospital, McGill University, Montreal, QC, Canada H3H 1P3
4Division of Pediatric Neurology, Department of Pediatrics, Montreal Children’s Hospital, McGill University, Montreal, QC, Canada H3H 1P3

Received 5 April 2015; Revised 14 June 2015; Accepted 15 June 2015

Academic Editor: Clive R. Bramham

Copyright © 2015 Saskia Kwan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Azzopardi, B. Strohm, N. Marlow et al., “Effects of hypothermia for perinatal asphyxia on childhood outcomes,” The New England Journal of Medicine, vol. 371, no. 2, pp. 140–149, 2014. View at Publisher · View at Google Scholar
  2. S. E. Jacobs, M. Berg, R. Hunt, W. O. Tarnow-Mordi, T. E. Inder, and P. G. Davis, “Cooling for newborns with hypoxic-ischemic encephalopathy,” The Cochrane Database of Systematic Reviews, vol. 1, Article ID CD003311, 2013. View at Publisher · View at Google Scholar
  3. S. Shankaran, A. Pappas, S. A. McDonald et al., “Childhood outcomes after hypothermia for neonatal encephalopathy,” The New England Journal of Medicine, vol. 366, pp. 2085–2092, 2012. View at Google Scholar
  4. T. E. Inder, R. W. Hunt, C. J. Morley et al., “Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy,” The Journal of Pediatrics, vol. 145, no. 6, pp. 835–837, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Rutherford, L. A. Ramenghi, A. D. Edwards et al., “Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial,” The Lancet Neurology, vol. 9, no. 1, pp. 39–45, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Cavalleri, L. Lugli, M. Pugliese et al., “Prognostic value of diffusion-weighted imaging summation scores or apparent diffusion coefficient maps in newborns with hypoxic-ischemic encephalopathy,” Pediatric Radiology, vol. 44, pp. 1141–1154, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Rutherford, S. Counsell, J. Allsop et al., “Diffusion-weighted magnetic resonance imaging in term perinatal brain injury: a comparison with site of lesion and time from birth,” Pediatrics, vol. 114, no. 4, pp. 1004–1014, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. J. D. Winter, D. S. Lee, R. M. Hung et al., “Apparent diffusion coefficient pseudonormalization time in neonatal hypoxic-ischemic encephalopathy,” Pediatric Neurology, vol. 37, no. 4, pp. 255–262, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. R. L. Wolf, R. A. Zimmerman, R. Clancy, and J. H. Haselgrove, “Quantitative apparent diffusion coefficient measurements in term neonates for early detection of hypoxic-ischemic brain injury: initial experience,” Radiology, vol. 218, no. 3, pp. 825–833, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. R. C. McKinstry, J. H. Miller, A. Z. Snyder et al., “A prospective, longitudinal diffusion tensor imaging study of brain injury in newborns,” Neurology, vol. 59, no. 6, pp. 824–833, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Ward, S. Counsell, J. Allsop et al., “Reduced fractional anisotropy on diffusion tensor magnetic resonance imaging after hypoxic-ischemic encephalopathy,” Pediatrics, vol. 117, no. 4, pp. e619–e630, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. A. J. Barkovich, “MR imaging of the neonatal brain,” Neuroimaging Clinics of North America, vol. 16, no. 1, pp. 117–135, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Boichot, P. M. Walker, C. Durand et al., “Term neonate prognoses after perinatal asphyxia: contributions of MR imaging, MR spectroscopy, relaxation times, and apparent diffusion coefficients,” Radiology, vol. 239, no. 3, pp. 839–848, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. S. K. Goergen, H. Ang, F. Wong et al., “Early MRI in term infants with perinatal hypoxic-ischaemic brain injury: Interobserver agreement and MRI predictors of outcome at 2 years,” Clinical Radiology, vol. 69, no. 1, pp. 72–81, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. A. J. Barkovich, S. P. Miller, A. Bartha et al., “MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy,” American Journal of Neuroradiology, vol. 27, no. 3, pp. 533–547, 2006. View at Google Scholar · View at Scopus
  16. M. Rutherford, L. Srinivasan, L. Dyet et al., “Magnetic resonance imaging in perinatal brain injury: clinical presentation, lesions and outcome,” Pediatric Radiology, vol. 36, no. 7, pp. 582–592, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Wintermark, A. Hansen, J. Soul, M. Labrecque, R. L. Robertson, and S. K. Warfield, “Early versus late MRI in asphyxiated newborns treated with hypothermia,” Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 96, no. 1, pp. F36–F44, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. A. J. Barkovich, K. D. Westmark, H. S. Bedi, J. C. Partridge, D. M. Ferriero, and D. B. Vigneron, “Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary report,” American Journal of Neuroradiology, vol. 22, no. 9, pp. 1786–1794, 2001. View at Google Scholar · View at Scopus
  19. O. Brissaud, M. Amirault, F. Villega, O. Periot, J. F. Chateil, and M. Allard, “Efficiency of fractional anisotropy and apparent diffusion coefficient on diffusion tensor imaging in prognosis of neonates with hypoxic-ischemic encephalopathy: a methodologic prospective pilot study,” American Journal of Neuroradiology, vol. 31, no. 2, pp. 282–287, 2010. View at Publisher · View at Google Scholar
  20. J. S. Coats, A. Freeberg, E. G. Pajela, A. Obenaus, and S. Ashwal, “Meta-analysis of apperant diffusion coefficients in the newborn brain,” Pediatric Neurology, vol. 41, no. 4, pp. 263–274, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. J. D. Hanrahan, I. J. Cox, D. Azzopardi et al., “Relation between proton magnetic resonance spectroscopy within 18 hours of birth asphyxia and neurodevelopment at 1 year of age,” Developmental Medicine & Child Neurology, vol. 41, no. 2, pp. 76–82, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. C. L'Abee, L. S. de Vries, J. van der Grond, and F. Groenendaal, “Early diffusion-weighted MRI and 1H-magnetic resonance spectroscopy in asphyxiated full-term neonates,” Biology of the Neonate, vol. 88, no. 4, pp. 306–312, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Liauw, G. van Wezel-Meijler, S. Veen, M. A. van Buchem, and J. van der Grond, “Do apparent diffusion coefficient measurements predict outcome in children with neonatal hypoxic-ischemic encephalopathy?” The American Journal of Neuroradiology, vol. 30, no. 2, pp. 264–270, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Thayyil, M. Chandrasekaran, A. Taylor et al., “Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis,” Pediatrics, vol. 125, no. 2, pp. e382–e395, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. P. S. Hüppi and J. Dubois, “Diffusion tensor imaging of brain development,” Seminars in Fetal and Neonatal Medicine, vol. 11, no. 6, pp. 489–497, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Rutherford, P. Ward, J. Allsop, C. Malamatentiou, and S. Counsell, “Magnetic resonance imaging in neonatal encephalopathy,” Early Human Development, vol. 81, no. 1, pp. 13–25, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. N. Bednarek, A. Mathur, T. Inder, J. Wilkinson, J. Neil, and J. Shimony, “Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy,” Neurology, vol. 78, no. 18, pp. 1420–1427, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. S. L. Bonifacio, A. Saporta, H. C. Glass et al., “Therapeutic hypothermia for neonatal encephalopathy results in improved microstructure and metabolism in the deep gray nuclei,” American Journal of Neuroradiology, vol. 33, no. 11, pp. 2050–2055, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Gano, V. Chau, K. J. Poskitt et al., “Evolution of pattern of injury and quantitative MRI on days 1 and 3 in term newborns with hypoxic-ischemic encephalopathy,” Pediatric Research, vol. 74, no. 1, pp. 82–87, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Neil, “Is MRI still cool after hypothermia?” The Lancet Neurology, vol. 9, no. 1, pp. 19–20, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. N. H. Thakur, A. J. Spencer, H. W. Kilbride, and L. H. Lowe, “Findings and patterns on MRI and MR spectroscopy in neonates after therapeutic hypothermia for hypoxic ischemic encephalopathy treatment,” Southern Medical Journal, vol. 106, no. 6, pp. 350–355, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. M. A. Rutherford, D. Azzopardi, A. Whitelaw et al., “Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy,” Pediatrics, vol. 116, no. 4, pp. 1001–1006, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. E. C. C. Lee, N. S. Kwatra, G. Vezina, and Z. P. Khademian, “White matter integrity on fractional anisotropy maps in encephalopathic neonates post hypothermia therapy with normal-appearing MR imaging,” Pediatric Radiology, vol. 43, no. 6, pp. 709–715, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. A. N. Massaro, N. Kadom, T. Chang, P. Glass, K. Nelson, and S. Baumgart, “Quantitative analysis of magnetic resonance images and neurological outcome in encephalopathic neonates treated with whole-body hypothermia,” Journal of Perinatology, vol. 30, no. 9, pp. 596–603, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Wintermark, M. Labrecque, S. K. Warfield, S. Dehart, and A. Hansen, “Can induced hypothermia be assured during brain MRI in neonates with hypoxic-ischemic encephalopathy?” Pediatric Radiology, vol. 40, no. 12, pp. 1950–1954, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. A. J. Barkovich, B. L. Hajnal, D. Vigneron et al., “Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems,” American Journal of Neuroradiology, vol. 19, no. 1, pp. 143–149, 1998. View at Google Scholar · View at Scopus
  37. American Academy of Pediatrics, “Neonatal Encephalopathy and Neurologic Outcome, Second Edition,” Pediatrics, vol. 133, no. 5, pp. e1482–e1488, 2014. View at Publisher · View at Google Scholar
  38. “Executive summary: neonatal encephalopathy and neurologic outcome, second edition. Report of the American College of Obstetricians and Gynecologists’ Task Force on Neonatal Encephalopathy,” Obstetrics & Gynecology, vol. 123, no. 4, pp. 896–901, 2014. View at Publisher · View at Google Scholar
  39. E. Boudes, X. Tan, C. Saint-Martin, M. Shevell, and P. Wintermark, “MRI obtained during versus after hypothermia in asphyxiated newborns,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 100, no. 3, pp. F238–F242, 2015. View at Publisher · View at Google Scholar
  40. S. M. Smith, “Fast robust automated brain extraction,” Human Brain Mapping, vol. 17, no. 3, pp. 143–155, 2002. View at Publisher · View at Google Scholar · View at Scopus
  41. E. Garyfallidis, M. Brett, B. Amirbekian et al., “Dipy, a library for the analysis of diffusion MRI data,” Frontiers in Neuroinformatics, vol. 8, article 8, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Wintermark, A. Hansen, M. C. Gregas et al., “Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia,” The American Journal of Neuroradiology, vol. 32, no. 11, pp. 2023–2029, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. C. A. Schneider, W. S. Rasband, and K. W. Eliceiri, “NIH Image to ImageJ: 25 years of image analysis,” Nature Methods, vol. 9, no. 7, pp. 671–675, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. D. Le Bihan, J. Delannoy, and R. L. Levin, “Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia,” Radiology, vol. 171, no. 3, pp. 853–857, 1989. View at Publisher · View at Google Scholar · View at Scopus
  45. H. Bouza, L. M. S. Dubowitz, M. Rutherford, and J. M. Pennock, “Prediction of outcome in children with congenital hemiplegia: a magnetic resonance imaging study,” Neuropediatrics, vol. 25, no. 2, pp. 60–66, 1994. View at Publisher · View at Google Scholar · View at Scopus
  46. L. S. de Vries, J. van Der Grond, I. C. van Haastert, and F. Groenendaal, “Prediction of outcome in new-born infants with arterial ischaemic stroke using diffusion-weighted magnetic resonance imaging,” Neuropediatrics, vol. 36, no. 1, pp. 12–20, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. A. N. Massaro, I. Evangelou, A. Fatemi et al., “White matter tract integrity and developmental outcome in newborn infants with hypoxic-ischemic encephalopathy treated with hypothermia,” Developmental Medicine & Child Neurology, vol. 57, no. 5, pp. 441–448, 2015. View at Publisher · View at Google Scholar
  48. C. Limperopoulos, J. S. Soul, H. Haidar et al., “Impaired trophic interactions between the cerebellum and the cerebrum among preterm infants,” Pediatrics, vol. 116, no. 4, pp. 844–850, 2005. View at Publisher · View at Google Scholar · View at Scopus