Evolution of Apparent Diffusion Coefficient and Fractional Anisotropy in the Cerebrum of Asphyxiated Newborns Treated with Hypothermia over the First Month of Life

Table 2

Comparison of apparent diffusion coefficient (ADC) values (×10⁻³ mm²/s) in each region of interest between healthy newborns and asphyxiated newborns treated with hypothermia developing or not brain injury, on day 1 of life, on days 2-3 of life, around day 10 of life, and around day 30 of life.

	Thalamus	Posterior limb of internal capsule	Lentiform nucleus	Anterior white matter	Posterior white matter	Frontal cortical grey matter	Parietal cortical grey matter	Occipital cortical grey matter
On day 1 of life
Healthy newborns	1.076 ± 0.031 ()	1.085 ± 0.041 ()	1.144 ± 0.016 ()	1.760 ± 0.086 ()	1.494 ± 0.135 ()	1.208 ± 0.096 ()	1.128 ± 0.055 ()	1.080 ± 0.084 ()
Asphyxiated newborns—no injury	1.014 ± 0.044 ()	1.018 ± 0.052 ()	1.096 ± 0.056 ()	1.634 ± 0.113 ()	1.444 ± 0.085 ()	1.042 ± 0.050 ()	1.005 ± 0.053 ()	0.959 ± 0.053 ()
Asphyxiated newborns—injury	0.891 ± 0.179 ()	0.960 ± 0.137 ()	1.008 ± 0.130 ()	1.522 ± 0.114 ()	1.451 ± 0.036 ()		0.936 ± 0.062 ()
value: no injury versus healthy	0.006	0.012	0.025	0.008	ns	0.0005	0.0002	0.002
value: injury versus healthy	0.0003	0.0006	0.0002	—	—	—	0.004	—
value: injury versus no injury	0.010	ns	0.042	—	—	—	ns (0.069)	—
On days 2-3 of life
Healthy newborns	1.075 ± 0.036 ()	1.111 ± 0.029 ()	1.177 ± 0.027 ()	1.709 ± 0.147 ()	1.477 ± 0.115 ()	1.210 ± 0.085 ()	1.138 ± 0.056 ()	1.124 ± 0.059 ()
Asphyxiated newborns—no injury	1.019 ± 0.058 ()	1.033 ± 0.058 ()	1.109 ± 0.063 ()	1.558 ± 0.123 ()	1.448 ± 0.121 ()	1.084 ± 0.074 ()	1.026 ± 0.051 ()	1.030 ± 0.078 ()
Asphyxiated newborns—injury	0.891 ± 0.204 ()	0.925 ± 0.144 ()	0.975 ± 0.175 ()	1.447 ± 0.121 ()	1.312 ± 0.171 ()	1.030 ± 0.082 ()	0.963 ± 0.102 ()	1.002 ± 0.073 ()
value: no injury versus healthy	0.016	0.002	0.005	0.018	ns	0.001	0.0002	0.001
value: injury versus healthy	0.003	<0.0001	<0.0001	0.001	ns (0.050)	—	0.0004	0.0003
value: injury versus no injury	0.011	0.004	0.0002	0.018	0.015	—	0.043	ns (0.078)
Around day 10 of life
Healthy newborns	1.061 ± 0.017 ()	1.098 ± 0.022 ()	1.152 ± 0.014 ()	1.671 ± 0.111 ()	1.480 ± 0.077 ()	1.171 ± 0.037 ()	1.118 ± 0.064 ()	1.116 ± 0.043 ()
Asphyxiated newborns—no injury	1.090 ± 0.055 ()	1.102 ± 0.051 ()	1.170 ± 0.062 ()	1.675 ± 0.118 ()	1.678 ± 0.121 ()	1.171 ± 0.061 ()	1.123 ± 0.049 ()	1.133 ± 0.068 ()
Asphyxiated newborns—injury	1.154 ± 0.111 ()	1.120 ± 0.105 ()	1.201 ± 0.119 ()	1.725 ± 0.163 ()	1.622 ± 0.082 ()	1.211 ± 0.044 ()	1.124 ± 0.051 ()	1.132 ± 0.052 ()
value: no injury versus healthy	ns	ns	ns	ns	0.0004	ns	ns	ns
value: injury versus healthy	0.020	ns	ns	ns	0.0002	0.001	ns	ns
value: injury versus no injury	0.009	ns	ns	ns	ns	0.015	ns	ns
Around day 30 of life
Healthy newborns	1.020 ± 0.033 ()	1.040 ± 0.043 ()	1.086 ± 0.022 ()	1.508 ± 0.069 ()	1.379 ± 0.041 ()	1.082 ± 0.039 ()	1.055 ± 0.055 ()	1.113 ± 0.078 ()
Asphyxiated newborns—no injury	1.029 ± 0.045 ()	1.052 ± 0.044 ()	1.110 ± 0.056 ()	1.607 ± 0.182 ()	1.609 ± 0.179 ()	1.141 ± 0.062 ()	1.100 ± 0.051 ()	1.112 ± 0.063 ()
Asphyxiated newborns—injury	1.040 ± 0.052 ()	1.068 ± 0.044 ()	1.110 ± 0.062 ()	1.682 ± 0.207 ()	1.618 ± 0.110 ()	1.136 ± 0.058 ()	1.120 ± 0.050 ()	1.139 ± 0.056 ()
value: no injury versus healthy	ns	ns	ns	ns	0.022	0.009	ns (0.052)	ns
value: injury versus healthy	ns	ns	ns	0.043	<0.0001	—	0.026	—
value: injury versus no injury	ns	ns	ns	ns	ns	—	ns	—

Mean ± standard deviation.
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