Multiscale Modeling Indicates That Temperature Dependent [Ca²⁺]_i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity

Figure 5

Dependence of the mean period on the pump strength . (a) exhibits a nonlinear dependence on the pump strength with a minimal mean period of 42 s for  s⁻¹. This might illuminate a possible control mechanism cells can use to tune their oscillations. (b) The - relation exhibits a population slope close to one and a deterministic time of approximately 20 s. (c) The height of the local Ca²⁺ concentration close to a cluster is hardly affected by as demonstrated by the representative example of the same cluster in different simulations using different pump rates. Hence, the differences in the cytosolic Ca²⁺ oscillations in Figure 3(b) are spatially induced.

(a)

(b)

(c)