Multiscale Modeling Indicates That Temperature Dependent [Ca2+]i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity
Dependence of the mean period on the pump strength . (a) exhibits a nonlinear dependence on the pump strength with a minimal mean period of 42 s for s−1. This might illuminate a possible control mechanism cells can use to tune their oscillations. (b) The - relation exhibits a population slope close to one and a deterministic time of approximately 20 s. (c) The height of the local Ca2+ concentration close to a cluster is hardly affected by as demonstrated by the representative example of the same cluster in different simulations using different pump rates. Hence, the differences in the cytosolic Ca2+ oscillations in Figure 3(b) are spatially induced.
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