Fractalkine Signaling and Microglia Functions in the Developing Brain

Figure 1

Fractalkine/CX3CR1 signaling controls survival of cortical neuron during early postnatal development. (a) Apoptotic cells revealed by TUNEL staining in the cortex of Cx3cr1^+/GFP (top) and Cx3cr1^GFP/GFP (bottom) mice at P5. Scale bar represents 100 μm. The arrowheads indicate TUNEL-positive elements in the layer V of the cortex. (b) Quantification of the TUNEL-positive cells density in different cortical layers. Note the increase of apoptotic cells in the layer V and II–IV in the cortex of Cx3cr1^GFP/GFP. Adapted from [43].

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