Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease

Figure 1

Electroencephalographic (EEG) characteristics of controls and 5XFAD mice. EEGs recorded from the primary motor cortex (M1) as electrocorticogram (ECoG) (a) and the hippocampal CA1 region as electrohippocampogram (b) from both WT and 5XFAD mice. In the CA1 electrohippocampogram neither controls (b)I nor 5XFAD mice (b)II exhibited typical ictal discharges in 48 h long-term recordings. Electrocorticographic M1 recordings, however, exhibited subclinical, that is, electroencephalographic seizure activity in 5XFAD mice of different severity (a)II that was not detectable in control mice (a)I. (a)I, (b)I, and b(II): 30 sec duration; (a)II 50 sec duration.

(a)

(b)