Dopaminergic Modulation of Striatal Inhibitory Transmission and Long-Term Plasticity

Figure 9

Synaptic plasticity in the striatal degeneration. (a) shows representative traces of IPSC before (top) and after HFS (middle) and an overlap of the traces (bottom). Note that LTP is produced after HFS. (b) illustrates the time course of the IPSC amplitude before and after HFS. (c) displays the percentage of cells that exhibited LTP after HFS in 3-NP-treated slices. (d) shows the PPR comparison of the IPSCs before and after HFS. (e) The rise time and (f) decay time constants before and after HFS. (g) shows representative IPSCs traces before (top) and after HFS (middle) in the presence of H89 (5 μM) and overlap of the traces (bottom). (h) Time course of the IPSC amplitude before and after HFS in the presence of H89 (5 μM). Note that the block of PKA prevented the generation of LTP in 3-NP slices. (i) is the PPR comparison of the IPSCs before and after HFS in the presence of H89.