Genotype-Dependent Difference in 5-HT_2C Receptor-Induced Hypolocomotion: Comparison with 5-HT_2A Receptor Functional Activity

Figure 4

Functional activity of 5-H and 5-H receptors in seven inbred mouse strains. (a) The efficiency of locomotor activity reduction was calculated as the ratio (%) of the difference between the mean distance traveled by mice treated with saline and the mean distance traveled by mice treated with MK-212 related to the mean distance traveled by saline group. (b) Functional activity of 5-H receptor was estimated by number of 5-H receptor-mediated head-twitches induced by 5-H agonist DOI (1 mg/kg, i.p.). The data are presented as mean ± SEM ( per group; compared with C57Bl/6, ICR, DBA/2J, Asn, and Balb/c strains; compared with Balb/c strain).

(a)

(b)