Hippocampal Infusion of Zeta Inhibitory Peptide Impairs Recent, but Not Remote, Recognition Memory in Rats

Figure 1

Photographs at three coronal levels for a rat with hippocampal infusion of ZIP (anterior to posterior from left to right; lateral to the left of each section and medial to the right). Top: fluorescence images depicting the extent of the ZIP infusion throughout all cell layers of dorsal, intermediate, and ventral hippocampus, while remaining confined to the hippocampus. Some sparing was noted in the most medial aspects of the dorsal hippocampus. The only biotin-labeled ZIP outside of the hippocampus was the result of diffusion along the needle track. Bottom: corresponding tissue stained with thionin to visualize the hippocampal cell layers.