Neural Plasticity / 2015 / Article / Fig 3

Review Article

Odorant Receptors Signaling Instructs the Development and Plasticity of the Glomerular Map

Figure 3

OSNs in the OE and OR signaling pathways. (a) The OSN somas and cilia (dots), where the OR signaling pathways occur, transduce the information to the axons (lines) through action potentials that eventually reach the OB. (b) Diagram of the signaling pathway of a standard OR after activation. The interaction of odorants with their receptors on the OSN cilia and soma leads to Golf activation, which activates ACIII, thus causing increased cAMP levels. Next, cAMP activates CNG channels that allow the entry of sodium and calcium. Finally, this latter ion activates a chloride channel that contributes to depolarization enough to reach the threshold for action potentials. Modified from [38].

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.