P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction

Table 1

Pharmacological or genetic P2Y₁ receptor intervention and cognition in animals.

Cognitive domain	Pathological model	Drug/KO	Effect on P2Y1R	Appl.	Species	Behavioural task	Effects	Reference
Aversive memory	pMCAO	MRS 2500	Antagonist	i.c.v.	Mice	Passive avoidance test	n.s.	[146]
Fear-based learning	MCAO	MRS 2500	Antagonist	i.c.v	Mice	Contextual fear conditioning test	Reversal of deficit	[147]
	MCAO	P2Y1R KO	Knockout			Contextual fear conditioning test	Reversal of deficit	[147]
Recognition memory	pMCAO	MRS 2500	Antagonist	i.c.v.	Mice	Object recognition test	Reversal of deficit	[146]
Spatial memory	pMCAO	MRS 2500	Antagonist	i.c.v.	Mice	Morris water maze	Reversal of deficit	[146]
	Controlled cortical impact injury	MRS 2179	Antagonist	i.c.v.	Mice	Morris water maze	Reversal of deficit	[148]
Working memory	pMCAO	MRS 2500	Antagonist	i.c.v.	Mice	Y-maze test	Reversal of deficit	[146]
		MRS 2365	Agonist	Bilateral infusion into PFC	Rats	DNMTP task	Impairment	[44]
Reversal learning		MRS 2365	Agonist	Bilateral infusion into PFC	Rats	Reversal learning task	Impairment	[44]
Sensory-motor gating		MRS 2365	Agonist	Bilateral infusion into PFC	Rats	PPI of acoustic startle response	Attenuation	[44]

Appl., application; DNMTP, delayed nonmatching to position; i.c.v., intracerebroventricular; KO, knockout; MCAO, middle cerebral artery occlusion; n.s., nonsignificant; P2Y₁R, P2Y₁ receptor; PFC, prefrontal cortex; pMCAO, permanent middle cerebral artery occlusion; PPI, prepulse inhibition.