Bilateral Neuropathy of Primary Sensory Neurons by the Chronic Compression of Multiple Unilateral DRGs

Figure 8

CGRP expression was significantly increased in large- and medium-sized neurons but not in small-sized neurons in ipsilateral and contralateral DRGs following the mCCD. (a) CGRP expression in ipsilateral large- and medium-sized DRG neurons in control and mCCD rats (on 10th postoperative day, inset: higher magnification, scale bar = 20 μm). (b) CGRP expression in ipsilateral small-sized DRG neurons in control and mCCD rats (on 10th postoperative day; inset: higher magnification, scale bar = 20 μm). (c) Percentage of CGRP positive cells in ipsilateral and contralateral DRGs following the multiple DRG compression on the 1st, 7th, 10th, 14th, and 21st postoperative day. (d) The percentage of CGRP positive cells in ipsilateral and contralateral large- and medium-sized DRG neurons was significantly increased following the chronic compression of DRGs. (e) The percentage of CGRP positive small-sized neurons in ipsilateral and contralateral DRGs was significantly increased following the chronic compression of DRGs. Scale bar = 50 μm (a-b). Bonferroni test, , compared to the bilateral DRG neurons of control rats.

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