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Neural Plasticity
Volume 2016, Article ID 2173748, 23 pages
Review Article

Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models

1School of Psychology, University of Nottingham, Nottingham NG7 2RD, UK
2School of Medicine, University College Cork, Brookfield Health Sciences Complex, College Road, Cork, Ireland
3School of Life Sciences, University of Glasgow, Room 220, Bower Building, Glasgow G12 8QQ, UK
4Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
5Jiangsu Key Laboratory of Translational Research & Therapy for Neuropsychiatric Disorders and Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China

Received 27 March 2016; Revised 20 July 2016; Accepted 21 August 2016

Academic Editor: Joram Feldon

Copyright © 2016 Paula Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets. This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed. It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia.