Research Article

Value of Functionalized Superparamagnetic Iron Oxide Nanoparticles in the Diagnosis and Treatment of Acute Temporal Lobe Epilepsy on MRI

Figure 5

NF-kappa B p65 expression and astrocyte hyperplasia in the hippocampus CA3 of epileptic rats treated with anti-IL-1β mAb-SPIONs versus saline and P-SPIONs (20x); ((a1)–(b4)) show the activation of GFAP-positive astrocytes and the expression of NF-kappa B p65 in astrocyte nucleus was observed in the saline ((a1)–(a4)) and P-SPIONs groups ((b1)–(b4)). Colocalization panels ((a4)–(c4)) show NF-B p65 expression in activated astrocytes in the hippocampus CA3 of epileptic rats; (c4) notes the inhibition of NF-B p65 nucleus transfer in anti-IL-1β mAb-SPIONS-treated rats; (c1) shows that the astrocytes still have an activated phenotype. (d) shows the number of positive-GFAP astrocytes (mean ± SD, ). versus saline group.
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