Lasting Differential Effects on Plasticity Induced by Prenatal Stress in Dorsal and Ventral Hippocampus

Figure 2

Effect of Isoproterenol, aβ-adrenergic agonist, on EPSPs recorded in stratum radiatum of DH (a) and VH (b) hippocampal slices from control and prenatally stressed (PS) rats (at 2-3 weeks of gestation). The arrows denote the points at which short tetanic stimulation (35 stimuli at 100 Hz) was delivered, twice to one pathway. Short tetanic stimulation, which normally produces only short-term potentiation, applied in the presence of Isoproterenol, produced a full-blown LTP in DH slices of control group (full circles, (a)) and in VH slices of PS rats (open circles, (b)), but not in the other conditions tested (adapted from Grigoryan and Segal [60]).

(a) DH

(b) VH