Transplantation of Neural Stem Cells Cotreated with Thyroid Hormone and GDNF Gene Induces Neuroprotection in Rats of Chronic Experimental Allergic Encephalomyelitis

Figure 3

HE staining of inflammatory lesions of the cerebral parenchyma and LFB staining of demyelination of the corpus callosum in control, NSCs, T3/NSCs, and GDNF-T3/NSCs groups, respectively. (a) Control group showed much more inflammatory cell infiltrations. ((b), (c), and (d)) Neurosphere-treated groups displayed reduced number and size of inflammatory cell infiltrations, especially in GDNF-T3/NSCs groups (d). (e) Control group showed marked myelin sparse and loss. ((f), (g), and (h)) Neurosphere-treated groups displayed a preservation of the myelin structure, especially in GDNF-T3/NSCs groups (h). (a–d) = 50 μm, (e–h) = 100 μm.

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