Figure 3: Environmental factors influencing neuroinflammation in autism. Early inflammation in the brain is a well-recognized risk factor for autism. Neuroinflammation is a process influenced by environmental factors such as MIA, microbiota, and n-3 PUFAs deficiency. However, crosstalks between these factors can make the situation increasingly complex. For instance, insufficient dietary n-3 PUFAs intake unavoidably impacts microbiota composition as well as MIA immunoreactivity possibly potentiating the proinflammatory response. This, in turn, can lead to increased risks for autism.