Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease

Figure 3

Time-course analysis of phosphorylation changes of ERK1/2 during LTP in WT and NPC1−/− mice. Representative Western Blots of phosphorylated and total form of ERKs are shown in the upper panels. Densitometric quantitation of the immunoreactive bands at different times after LTP induction is illustrated in the lower panel. Values represent the normalized percent changes in ERK2 protein phosphorylation for each time point after LTP. Bars in the plots represent means ± SEM ( for WT mice, versus control values (T0); for NPC1−/− mice, versus WT mice at the corresponding time point).